Potential Regulatory Role of miR-21 on Alzheimer’s Disease by Targeting GSK-3β Signaling

Background: Alzheimer’s disease (AD) is the most important neurogenerative disorder with progressive dementia as its main clinical manifestation. The microRNAs (miRNAs) are identified crucial modulators in AD progression. Nevertheless, biological potential of miR-21 obscure. Hence, this study aimed to evaluate possible role pathogenesis via phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta (GSK-3β) signaling. Materials and Methods: expression brain tissues patients AD, well normal Aβ1-42-stimulated SH-SY5Y cell line (AD model) was examined by situ hybridization quantitative real-time polymerase chain reaction. Also, apoptosis-linked protein levels programmed death 4 (PDCD4) were detected western blot. Results: Our findings revealed that low expressed model (P<0.01). overexpression could inhibit apoptosis Indeed, negatively regulated PDCD4 expression, which led activated PI3K/AKT/GSK-3β Conclusion: demonstrated cloud inhibits through activation signaling pathway using inhibition expression.